Drug Abuse and Conduct Disorder Linked to Maternal Smoking During Pregnancy
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Raymond Varisco
Raymond Varisco is a Contributing Writer for NIDA NOTES.
Source: NIDA NOTES, Vol.15, No. 5, October, 2000
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Article: Drug Abuse and Conduct Disorder Linked to Maternal Smoking During PregnancyReferences
Researchers at Columbia University in New York City have
found new evidence that children whose mothers smoke during
pregnancy are at much greater risk than other children for
drug abuse and conduct disorder. The findings reinforce
those of other studies spanning more than 25 years that
have shown similar problems associated with prenatal exposure
to smoke in children ranging from toddlers through teens.
The study also revealed marked gender differences, with
girls at significantly increased risk for drug abuse and
boys at significantly increased risk for conduct disorder.
The investigators interviewed 147 mother-child pairs 3 times over 10 years, with the children ranging from ages 6 to 23 at the start of the study. Both mothers and children were interviewed on entry into the study, again 2 years after the initial interview, and, finally, about 10 years after the initial interview. Because the researchers followed the children through either adolescence or young adulthood-something few studies have done before-they were able to collect data about whether and when the children began to abuse drugs, says Dr. Myrna Weissman, the study’s principal investigator.
Data were gathered on psychiatric and substance abuse disorders of parents; family environmental factors, such as divorce and family discord; and maternal factors, such as alcohol and coffee consumption and postnatal smoking, to rule out other explanations for the presence of drug abuse and conduct disorder.
The researchers found that maternal smoking during pregnancy
has long-term effects on children’s behavior and health
that cannot be explained by any other factor included in
the study. Risk for adolescent drug abuse in girls was more
than 5-fold higher if their mothers smoked more than 10
cigarettes a day during pregnancy. Among boys whose mothers
smoked more than 10 cigarettes a day, risk for the onset
of conduct disorder was greater than 4-fold that of boys
whose mothers did not smoke, with the increase appearing
in boys younger than 13. The drug most frequently abused
by both boys and girls was marijuana, and the most frequent
combination of drugs abused was marijuana and cocaine. Of
the females who abused drugs, 70 percent abused more than
one.
Why boys exposed to smoking before birth should be at risk for conduct disorder and girls at risk for drug abuse remains to be understood, Dr. Weissman says. She speculates that the differences may be related to sex differences in prenatal brain development.
Many of the findings of this study are consistent with those of related studies, she notes. Researchers at the University of Chicago also have found a link between maternal smoking during pregnancy and conduct disorder in boys, she says. Likewise, a 1994 study conducted by Dr. Weissman’s coinvestigator Dr. Denise Kandel found that maternal smoking during pregnancy increases risk for adolescent-onset smoking in girls. Studies also have found other behavioral problems in children exposed prenatally to smoke. For example, scientists at Massachusetts General Hospital found an association between prenatal exposure to smoke and attention deficit hyperactivity disorder. Similarly, a recent study by Dr. Judith Brook and her colleagues at Mount Sinai School of Medicine in New York City has found negative behavior in 2-year-olds of mothers who smoked during pregnancy.
Brook, J.S.; Brook, D.W.; and Whiteman, M. The influence of maternal smoking during pregnancy on the toddler’s negativity. Archives of Pediatrics and Adolescent Medicine 154:381-385, 2000.
Kandel, D.B.; Wu, P.; and Davies, M. Maternal smoking during pregnancy and smoking by adolescent daughters. American Journal of Public Health 84:1407-1413, 1994.
Wakschlag, L.S; Lahey, B.B.; Loeber, R.; Green, S.M.; Gordon, R.A.; and Leventhal, B.L. Maternal smoking during pregnancy and the risk of conduct disorder in boys. Archives of General Psychiatry 54:670-676, 1997.
Weissman, M.M.; Warner, V.; Wickramaratne, P.J.; and Kandel, D.B. Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood. Journal of the American Academy of Child and Adolescent Psychiatry 38:7, 1999.